Because of the UI for each column, the 1660 column count could be the issue. 5300 rows is not a problem at all. It shouldn’t crash, but it certainly won’t be fast. The recommended approach is to flatten the data (R calls it melt – https://www.r-bloggers.com/melt/) and DataGraph can handle 9 million rows.
To deal with the auto-save issue you need to dig into the library.
In ~/Library/Autosave Information – you will see any unsaved DataGraph files.
In ~/Library/Saved Application State/com.visualdatatools.datagraph.savedSate
the system stores the application state that is tries to restore upon launch. The Mac App store version doesn’t have access to those locations, so what the system does is to create a Container for the application and stores that in
~/Library/Containers/com.visualdatatools.datagraph/Data
There you will see the part that is visible to the application from your file system and in that has a library folder.
If you can share the file I would like to use it to stress test DataGraph. I can certainly create a file with that many rows and columns but maybe there is something else that is causing problems. Version 4.5 is able to display that size of a table, without any difficulties. Earlier versions will have problems with that many columns.